Kathy Rodriguez was born in Metairie, Louisiana, on July 16, 1980, during a heavy thunderstorm. She lived in Metairie and New Orleans before and after a brief 1998 stint in art school in Baltimore. She earned a B.A. in Studio Art at The University of New Orleans in 2004. In August 2005, she moved to Missoula to work towards both Master of Fine Arts in painting and drawing and Master of Arts in art history degrees at The University of Montana. In Missoula, she taught, painted, interned, and struggled to keep deer out of the garden. In late June, 2008, after graduating and teaching a summer painting course, she returned to New Orleans.

In addition to continuing her studio practice, Rodriguez now teaches at University of New Orleans and is a contributing writer for New Orleans Art Review and NOLA Defender. She also runs the UNO-St. Claude Gallery, the off-campus presence of the visual arts at the University of New Orleans, located in the experimental St. Claude Arts District.